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5-Bromo-4-chloro-3-indolyl phosphate disodium salt Cas:102185-33-1 White to off-white with light cream tinge crystalline powder

Short Description:

Catalog Number: XD90135
Cas: 102185-33-1
Molecular Formula: C8H4BrClNO4Na2P
Molecular Weight: 370.43
Availability: In Stock
Price:  
Prepack: 1g USD20
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Product Detail

Product Tags

Catalog Number XD90135
Product Name 5-Bromo-4-chloro-3-indolyl phosphate disodium salt
CAS 102185-33-1
Molecular Formula C8H4BrClNO4Na2P
Molecular Weight 370.43
Storage Details -15 to -20 °C
Harmonized Tariff Code 29339980

 

Product Specification

Appearance White to off-white with light cream tinge crystalline powder
Assay 99%
Solubility Clear and colorless solution ( Sol. 2%, water)
TLC 100%
H-NMR Spectrum Conforming to structure
Water ≤ 10.0%

 

The lung is a branched tubular network with two distinct compartments--the proximal conducting airways and the peripheral gas exchange region--separated by a discrete boundary termed the bronchoalveolar duct junction (BADJ). Here we image the developing mouse lung in three-dimensions (3D) and show that two nested developmental waves demarcate the BADJ under the control of a global hormonal signal. A first wave of branching morphogenesis progresses throughout embryonic development, generating branches for both compartments. A second wave of conducting airway differentiation follows the first wave but terminates earlier, specifying the proximal compartment and setting the BADJ. The second wave is terminated by a glucocorticoid signalling: premature activation or loss of glucocorticoid signalling causes a proximal or distal shift, respectively, in BADJ location. The results demonstrate a new mechanism of boundary formation in complex, 3D organs and provide new insights into glucocorticoid therapies for lung defects in premature birth.


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    5-Bromo-4-chloro-3-indolyl phosphate disodium salt Cas:102185-33-1 White to off-white with light cream tinge crystalline powder