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4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one Cas:951-77-9

Short Description:

Catalog Number: XD90580
Cas: 951-77-9
Molecular Formula: C9H13N3O4
Molecular Weight: 227.22
Availability: In Stock
Price:  
Prepack: 1g USD10
Bulk Pack: Request Quote

Product Detail

Product Tags

Catalog Number: XD90580
Cas: 951-77-9
Molecular Formula: C9H13N3O4
Molecular Weight: 227.22
Availability: In Stock
Price:  
Prepack: 1g USD10
Bulk Pack: Request Quote

 

Product Specification

Appearance White crystalline powder
Assay 99%
Melting Point 196°C - 200°C

 

Thymidine phosphorylase (TP, EC 2.4.2.4) recognized the structure of the substrate with high specificity, via both the base and the ribosyl moieties. The replacement of 3'-OH of thymidine markedly influenced its catalytic activity with TP. The conversion of pyrimidine nucleosides with modified base moieties to the corresponding 1-phosphate form was poor. The leaving group activity decreased with an increase in aromaticity of the pyrimidine base moiety, because of increased difficulty in polarizing the base by the amino acids local to the active site. The replacement of 3' and 5' functional groups tended to decrease the reaction rate and the percentage conversion with TP. In particular the ribosyl 3' hydroxyl group was structurally important for the binding of the substrate by the enzyme. The kinetic assay clearly showed high K(m) and low V(max) values on replacing the 3' hydroxyl group with hydrogen.


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    4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one Cas:951-77-9