2022 New Style Dutalys - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM
2022 New Style Dutalys - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM Detail:
Catalog Number | XD90306 |
Product Name | Poly-L-lysine solution ( 0.1%) |
CAS |
25988-63-0 |
Molecular Formula |
C18H38N6O4 |
Molecular Weight |
402.532124042511 |
Storage Details | 2-8°C |
Product Specification
Assay | 0.1% |
Appearance | Colorless liquid |
eucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of Parkinson’s disease (PD). The clinical features of LRRK2 PD are indistinguishable from idiopathic PD, with accumulation of α-synuclein and/or tau and/or ubiquitin in intraneuronal aggregates. This suggests that LRRK2 is a key to understanding the aetiology of the disorder. Although loss-of-function does not appear to be the mechanism causing PD in LRRK2 patients, it is not clear how this protein mediates toxicity. In this study, we report that LRRK2 overexpression in cells and in vivo impairs the activity of the ubiquitin-proteasome pathway, and that this accounts for the accumulation of diverse substrates with LRRK2 overexpression. We show that this is not mediated by large LRRK2 aggregates or sequestration of ubiquitin to the aggregates. Importantly, such abnormalities are not seen with overexpression of the related protein LRRK1. Our data suggest that LRRK2 inhibits the clearance of proteasome substrate s upstream of proteasome catalytic activity, favouring the accumulation of proteins and aggregate formation. Thus, we provide a molecular link between LRRK2, the most common known cause of PD, and its previously described phenotype of protein accumulation.
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Innovation, good quality and reliability are the core values of our enterprise. These principles today extra than ever form the basis of our success as an internationally active mid-size organization for 2022 New Style Dutalys - Poly-L-lysine solution ( 0.1%) Cas: 25988-63-0 – XD BIOCHEM , The product will supply to all over the world, such as: Sudan, Porto, Suriname, Our company has already had a lot of top factories and qualified technology teams in China, offering the best goods, techniques and services to worldwide customers. Honesty is our principle, skilled operation is our work, service is our goal, and customers' satisfaction is our future!
By Wendy from Tanzania - 2017.03.28 16:34
This is the first business after our company establish, products and services are very satisfying, we have a good start, we hope to cooperate continuous in the future!
By Michelle from Oman - 2018.12.14 15:26