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2-Oxobutyric acid CAS:600-18-0 colorless paste

Short Description:

Catalog Number: XD90263 
CAS: 600-18-0
Molecular Formula: C4H6O3
Molecular Weight: 102.089
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Prepack: 5g USD20
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Product Detail

Product Tags

Catalog Number XD90263 
Product Name 2-Oxobutyric acid
CAS 600-18-0
Molecular Formula C4H6O3
Molecular Weight 102.089
Storage Details -20 °C
Harmonized Tariff Code 2918300090

 

Product Specification

Density 1.182
Melting point 30-34 °C
Boiling point 84 °C
Appearance colorless paste
Assay 99%

 

1.Optically active D-2-hydroxybutanoate is an important building block intermediate for medicines and biodegradable poly(2-hydroxybutanoate). Kinetic resolution of racemic 2-hydroxybutanoate may be a green and desirable alternative for D-2-hydroxybutanoate production. In this work, D-2-hydroxybutanoate at a high concentration (0.197 M) and a high enantiomeric excess (99.1%) was produced by an NAD-independent L-lactate dehydrogenase (L-iLDH) containing biocatalyst. 2-Oxobutanoate, another important intermediate, was co-produced at a high concentration (0.193 M). Using a simple ion exchange process with the macroporous anion exchange resin D301, D-2-hydroxybutanoate was separated from the biotransformation system with a high recovery of 84.7%.

2.Asymmetric synthesis of an unnatural amino acid was demonstrated by omega-transaminase from Vibrio fluvialis JS17. L-2-Aminobutyric acid was synthesized from 2-oxobutyric acid and benzylamine with an enantiomeric excess higher than 99%. The reaction showed severe product inhibition by benzaldehyde, which was overcome by employing a biphasic reaction system to remove the inhibitory product from the aqueous phase. In a typical biphasic reaction (50 mM 2-oxobutyric acid, 70 mM benzylamine and 2.64 U/ml purified enzyme) using hexane as an extractant, conversion of 2-oxobutyric acid reached 96% in 5 h whereas only 39% conversion was obtained without the product extraction.


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    2-Oxobutyric acid CAS:600-18-0 colorless paste