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18 Years Factory Tris(Hydroxymethyl)Nitromethane - GSSG Cas: 27025-41-8 White crystalline powder – XD BIOCHEM

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18 Years Factory Tris(Hydroxymethyl)Nitromethane - GSSG Cas: 27025-41-8 White crystalline powder – XD BIOCHEM Detail:

Catalog Number XD90229
Product Name GSSG

CAS

27025-41-8

Molecular Formula

C20H32N6O12S2

Molecular Weight

612.631
Storage Details 2 to 8 °C

Harmonized Tariff Code

2930909899

 

Product Specification

Specific rotation -96 to -106
Heavy metals 10ppm max
AS 2ppm max
Loss on Drying 15.0% max.
Purity 95% min
Residue on Ignition 0.5% max
Appearance White crystalline powder
Assay 99%

 

Hepatotoxicity of drug candidates is one of the major concerns in drug screening in early drug discovery. Detection of hepatic oxidative stress can be an early indicator of hepatotoxicity and benefits drug selection. The glutathione (GSH) and glutathione disulfide (GSSG) pair, as one of the major intracellular redox regulating couples, plays an important role in protecting cells from oxidative stress that is caused by imbalance between prooxidants and antioxidants. The quantitative determination of the GSSG/GSH ratios and the concentrations of GSH and GSSG have been used to indicate oxidative stress in cells and tissues. In this study, we tested the possibility of using the biliary GSSG/GSH ratios as a biomarker to reflect hepatic oxidative stress and drug toxicity. Four compounds that are known to alter GSH and GSSG levels were tested in this study. Diquat (diquat dibromide monohydrate) and acetaminophen were administered to rats. Paraquat and tert-butyl hydroperoxide were administere d to mice to induce changes of biliary GSH and GSSG. The biliary GSH and GSSG were quantified using calibration curves prepared with artificial bile to account for any bile matrix effect in the LC-MS analysis and to avoid the interference of endogenous GSH and GSSG. With four examples (in rats and mice) of drug-induced changes in the kinetics of the biliary GSSG/GSH ratios, this study showed the potential for developing an exposure response index based on biliary GSSG/GSH ratios for predicting hepatic oxidative stress.

 


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18 Years Factory Tris(Hydroxymethyl)Nitromethane - GSSG  Cas: 27025-41-8  White crystalline powder – XD BIOCHEM detail pictures


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Now we have superior devices. Our solutions are exported to your USA, the UK and so on, enjoying a superb name between customers for 18 Years Factory Tris(Hydroxymethyl)Nitromethane - GSSG Cas: 27025-41-8 White crystalline powder – XD BIOCHEM , The product will supply to all over the world, such as: Cairo, Angola, Cairo, With strong technical strength and advanced production equipment, and SMS people purposefully , qualified, dedicated spirit of enterprise. Enterprises took the lead through the ISO 9001:2008 international quality management system certification, CE certification EU ; CCC.SGS.CQC other related product certification. We look forward to reactivating our company connection.
  • It is a very good, very rare business partners, looking forward to the next more perfect cooperation!
    5 Stars By Lee from Denver - 2018.11.11 19:52
    Production management mechanism is completed, quality is guaranteed, high credibility and service let the cooperation is easy, perfect!
    5 Stars By Moira from Hungary - 2018.06.05 13:10
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    18 Years Factory Tris(Hydroxymethyl)Nitromethane - GSSG Cas: 27025-41-8 White crystalline powder – XD BIOCHEM