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18 Years Factory Novo Nordisk - L-Hydroxyproline Cas: 51-35-4 White powder – XD BIOCHEM

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18 Years Factory Novo Nordisk - L-Hydroxyproline Cas: 51-35-4 White powder – XD BIOCHEM Detail:

Catalog Number XD90292
Product Name L-Hydroxyproline

CAS

51-35-4

Molecular Formula

C5H9NO3

Molecular Weight

131.13
Storage Details Ambient

Harmonized Tariff Code

2933998040

 

Product Specification

Assay 99%
Appearance White powder

 

Idiopathic pulmonary fibrosis is thought to involve lung injury caused by reactive oxygen species (ROS), which in turn is followed by abnormal fibrosis. A transforming growth factor (TGF)-β1-induced increase in myofibroblast number plays an important role in this abnormal fibrosis. We recently found that mepenzolate bromide (mepenzolate), which has been used clinically to treat gastrointestinal disorders, has ROS-reducing properties. In the present study, we examined the effect of mepenzolate on bleomycin-induced pulmonary fibrosis and lung dysfunction in mice. The severity of pulmonary fibrosis was assessed by histopathologic evaluation and determination of hydroxyproline levels. Lung mechanics (elastance) and respiratory function [forced vital capacity (FVC)] were assessed using a computer-controlled ventilator. Respiratory function was also evaluated by monitoring percutaneous arterial oxygen saturation (SpO2). Intratracheal administration of mepenzolate prior to bleomycin treatment reduced the extent of pulmonary fibrosis and changes in lung mechanics and led to a significant recovery of both FVC and SpO2 compared with control. Furthermore, mepenzolate produced a therapeutic effect even when it was administered after the development of fibrosis. Administration of mepenzolate also prevented bleomycin-induced pulmonary cell death and inflammatory responses and increased myofibroblast number. Mepenzolate also decreased NADPH oxidase activity and active TGF-β1 level or increased glutathione S-transferase (GST) activity in the presence of bleomycin treatment. These results show that the intratracheal administration of mepenzolate reduced bleomycin-induced pulmonary fibrosis and lung dysfunction in mice. These effects may be due to this drug’s inhibitory effect on NADPH oxidase and TGF-β1 activities and its stimulatory effect on GST.

 


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"Quality initially, Honesty as base, Sincere company and mutual profit" is our idea, in order to create repeatedly and pursue the excellence for 18 Years Factory Novo Nordisk - L-Hydroxyproline Cas: 51-35-4 White powder – XD BIOCHEM , The product will supply to all over the world, such as: Armenia, Stuttgart, Montpellier, The president and all the company members would like to provide professional products and services for customers and sincerely welcome and cooperate with all native and foreign customers for a bright future.
  • Perfect services, quality products and competitive prices, we have work many times, every time is delighted, wish continue to maintain!
    5 Stars By Elizabeth from Qatar - 2017.02.28 14:19
    After the signing of the contract, we received satisfactory goods in a short term, this is a commendable manufacturer.
    5 Stars By Salome from Lyon - 2017.09.29 11:19
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    18 Years Factory Novo Nordisk - L-Hydroxyproline Cas: 51-35-4 White powder – XD BIOCHEM